Follows the cellular and molecular programs that convert normal wound repair into persistent scar expansion, with emphasis on targetable fibroblast and keratinocyte states.

A high-value JID review reframes keloids as a multi-compartment disease involving fibroblasts, inflammation, adipocytes, genetic risk, and skin-of-color biology.

Keloid heterogeneity and adipocyte crosstalk

Decoding keloids links single-cell heterogeneity, adipocyte biology, biomarkers, and skin-of-color equity

The paper separates keloid-pathogenic signals from potentially therapeutic ASC states, suggesting cell therapy should be subpopulation-defined rather than bulk-ASC based.

Therapeutic ASC subpopulations in keloid

Single-cell profiling identifies therapeutic ASC subpopulations for human keloid management

Fibroblast states, keratinocyte-fibroblast crosstalk, ECM remodeling, metabolism, and antifibrotic targets.

瘢痕与瘢痕疙瘩生物学

Latest Daily Literature Reports

Decoding keloids links single-cell heterogeneity, adipocyte biology, biomarkers, and skin-of-color equity

Single-cell profiling identifies therapeutic ASC subpopulations for human keloid management